Skip to main content

A Controlled Clinical Trial of Cathodal DC Polarization in Patients with Refractory Epilepsy

Felipe Fregni, Sigride Thome-Souza, Michael Nitsche, Steven Freedman, Kette Valente, and Alvaro Pascual-Leone

autism neuroimaging study
autism neuroimaging study (Photo credit: Ian Ruotsala)
EEG Control Panel ca 1970
EEG Control Panel ca 1970 (Photo credit: Nils Geylen)
Some patients with epilepsy do not have an adequate seizure control with use of medications. For these patients, new therapeutic approaches have been investigated. In this context, brain stimulation might be a good therapeutic option. Therefore, we aimed to investigate the effects of a novel technique of noninvasive brain stimulation, namely brain DC polarization, in patients with refractory epilepsy. Nineteen patients with refractory seizures and malformations of cortical development participated in this study. DC polarization is a simple technique that induces a continuous (DC – direct current) electric current into the brain. In this technique, electric current flows from cathode to anode electrode; and, thus, its effects depend on the electrode polarity: cathodal stimulation inhibits brain activity and anodal stimulation facilitates it. Therefore we placed the cathode electrode over the epileptogenic area (that is, the brain area in which seizures are originated) and the anode electrode over the silent area (that is, the brain area with normal brain activity). We measured epileptic activity before and after the treatment using an electroencephalogram (EEG) and the frequency of seizures. The results of this study showed that active treatment (DC polarization) compared to sham treatment was associated with a significant decrease in the number of epileptiform discharges (abnormal brain activity in the EEG related to seizure activity) and a trend toward a significant decrease in the frequency of actual seizures. This treatment was not associated with detectable adverse effects. The results of this study encourage future investigations of this new method of brain stimulation for epilepsy treatment.
Enhanced by Zemanta
Post a Comment

Popular posts from this blog

What Is Continuous Spike-Wave in Slow Wave Sleep Syndrome? (A RARE EPILEPSY)

Image via Wikipedia Continuous spike-wave in slow wave sleep syndrome (CSWS) is a rare epilepsy syndrome in which children lose a wide range of developmental abilities, including language, motor skills, memory, and visuospatial skills. This syndrome occurs in school-aged children. Development prior to onset of CSWS may be normal, but children with CSWS often have some pre-existing learning difficulties. In many children there is no known cause of epilepsy, although some children are found to have abnormal brain formation or have a prior history of brain infection. We still do not understand how these structural changes result in the continuous EEG discharge.

Many, but not all, children with CSWS also have seizures. There can be many different seizure types, including absence, generalized tonic-clonic, and focal seizures. The seizures can be difficult to treat. Even in those who already had learning difficulties, there is a clear loss of skills across multiple deve…

Vitamin B12: The Most Important Nutrient You Need

Image via Wikipedia
Image by icethim via Flickr If you aren’t getting enough vitamin B12, it is indeed very important – and you may very well not be thinking about it. One reason you aren’t thinking about it is that we tend to fall in (and out!) of love with one nutrient at a time (such as vitamin C, beta carotene, lycopene and so on), and vitamin B12 isn’t the nutrient du jour. But the other reason you may not be thinking about it is … because you can’t. A deficiency of vitamin B12 can limit your ability to think clearly about anything! (More on that momentarily.)
Like all vitamins, B12 is an organic compound, made from carbons (as opposed to minerals, which are inorganic), and essential for our normal metabolic function and health. Also, like most vitamins, B12 plays a wide variety of roles in our metabolism. The short list of important effects B12 has on your health includes these: Vitamin B12 is essential for the manufacture of red blood cells; a deficiency leads to a cha…

Aloe Vera - diabetes, asthma, epilepsy, burns, sunburns, psoriasis and osteoarthritis

Introduction This fact sheet provides basic information about aloe vera—common names, uses, potential side effects, and resources for more information. Aloe vera's use can be traced back 6,000 years to early Egypt, where the plant was depicted on stone carvings. Known as the "plant of immortality," aloe was presented as a burial gift to deceased pharaohs.
What Aloe Vera Is Used ForTraditionally, aloe was used topically to heal wounds and for various skin conditions, and orally as a laxative.Today, in addition to traditional uses, people take aloe orally to treat a variety of conditions, including diabetes, asthma, epilepsy, and osteoarthritis. People use aloe topically for osteoarthritis, burns, sunburns, and psoriasis.Aloe vera gel can be found in hundreds of skin products, including lotions and sunblocks.The Food and Drug Administration (FDA) has approved aloe vera as a natural food flavoring. Aloe vera ...Lô Hội, Nha Đam..#1 (Photo credit: Vietnam Plants &…